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合成了环丙沙星铽荧光配合物 ,并研究其与 DNA分子的相互作用 .对比 DNA分子吸附配合物分子前后的显微红外及荧光光谱发现 ,以环丙沙星分子为配体的稀土配合物同 DNA间存在相互作用 ,这种作用诱导了 DNA二级结构的构象变化 .基于这种相互作用 ,研究了环丙沙星铽配合物对口腔粘膜组织切片的荧光染色 ,得到了同经典的苏木精 -伊红染色法类似的反差效果
Synthesis of terbium ciprofloxacin fluorescent complexes, and to study its interaction with DNA molecules.Compared with the DNA molecules adsorbed complex molecules before and after the microscopic infrared and fluorescence spectroscopy found that ciprofloxacin ligands for the rare earth complexes Interaction between DNA and DNA, which induces the conformational changes of DNA secondary structure.Based on this interaction, we studied the fluorescence staining of oral mucosal tissue slices of ciprofloxacin terbium complex, Similar contrast effect of hematoxylin-eosin staining