论文部分内容阅读
随着24h食管pH监测和胆汁监测技术的开展,胃、十二指肠液混合反流在胃食管反流病(GERD)的发生、发展中的作用已被逐步认识。胆汁反流在GERD发病过程中所扮演的角色,成为近年来人们研究的焦点之一。基础研究证明胆汁在不同酸碱环境、不同浓度对食管黏膜的损伤作用是不同的。不少临床试验对GERD进行研究发现,胆汁反流与症状和食管损伤严重度存在一定关系,但研究结果不尽一致,胆汁在GERD中的作用仍有争议。明确胆汁在GERD中的作用,有助于为预防此类疾病开辟新的道路。本文就有关胆汁反流在胃食管反流病中的作用的研究进展作一综述。
With the development of 24-hour esophageal pH monitoring and bile monitoring technology, the role of mixed reflux of gastric and duodenal fluid in the occurrence and development of gastroesophageal reflux disease (GERD) has been gradually recognized. The role of bile reflux in the pathogenesis of GERD has become one of the focuses of research in recent years. Basic research shows that bile in different acid-base environment, different concentrations of esophageal mucosal injury is different. Many clinical trials of GERD study found that bile reflux and symptoms and esophageal injury severity there is a certain relationship, but the results are not consistent, the role of bile in GERD is still controversial. Clarifying the role of bile in GERD helps to open new avenues for the prevention of such diseases. This article reviews the research progress on the role of bile reflux in gastroesophageal reflux disease.