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目的 探讨青年人大肠癌预后差的可能机制。方法 应用免疫组化ABC法检测转移抑制基因nm2 3蛋白产物核苷二磷酸激酶 (NDPK)在大肠癌中的表达。分析 >40岁和≤ 40岁的病人间表达的差异及与预后的关系。结果 nm2 3 (NDPK)的阳性表达率 >40岁组明显高于≤ 40岁组 (P <0 0 5 )。nm2 3 (NDPK)的表达与生存率呈正相关 (P <0 0 5 ) ,与转移复发率呈负相关 (P <0 0 5 )。结论 nm2 3 (NDPK)可作为大肠癌预后的判断指标。nm2 3 (NDPK)的低表达预示着肿瘤的高侵袭性和转移性 ,其可能是青年人大肠癌预后差的原因。
Objective To explore the possible mechanism of poor prognosis of colorectal cancer in young people. Methods Immunohistochemical ABC method was used to detect the expression of nm23 protein NNCK in colorectal cancer. Analysis of the differences between patients aged> 40 years and ≤40 years and their relationship with prognosis. Results The positive rate of nm23 (NDPK)> 40 years old was significantly higher than that of ≤ 40 years old (P <0 05). There was a positive correlation between the expression of nm23 (NDPK) and the survival rate (P <0.05), but negatively correlated with the recurrence rate (P <0.05). Conclusion nm 2 3 (NDPK) can be used as a prognostic indicator of colorectal cancer. The low expression of nm23 (NDPK) indicates the high invasion and metastasis of the tumor, which may be the reason of the poor prognosis of colorectal cancer in young people.