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应用Ｓ－Ｐ免疫组化法检测了７０例原发性肺癌及其癌旁组织的表皮生长因子受体（ＥＧＦＲ）表达，结果表明肺癌ＥＧＦＲ阳性率７７．１４％，ＥＧＦＲ阳性率及阳性程度与肺癌病理类型、肿瘤大小及是否发生淋巴结转移无相关性（Ｐ＞０．０５）。癌旁组织阳性率６８．２５％，增生组癌旁上皮细胞阳性率（８１．０３％）显著高于无增生组阳性率（４０．５４％）（Ｐ＜０．０５）。肺癌组织阳性率与增生组癌旁组织阳性率无统计学上的差异。认为ＥＧＦＲ在各型肺癌中的过度表达与肺癌的无限制生长有关，但不能作为肺癌恶性程度及预后的有效指标。ＥＧＦＲ过度表达在肺癌的发生中起重要作用，可能是肺癌发生的早期标志物。
The expression of epidermal growth factor receptor (EGFR) in 70 cases of primary lung cancer and adjacent tissues was detected by S-P immunohistochemical method. The results showed that the positive rate of EGFR in lung cancer was 77.14%, and the positive rate and positive rate of EGFR were similar. There was no correlation between pathological type, tumor size and lymph node metastasis (P>0.05). The positive rate of paracancerous tissue was 68.25%, and the positive rate of paracancerous epithelial cells in hyperplasia group (81.03%) was significantly higher than that in non-proliferative group (40.54%) (P<0.05). There was no statistical difference between the positive rate of lung cancer and the positive rate of adjacent tissues in the hyperplasia group. It is believed that overexpression of EGFR in lung cancers of various types is associated with the unlimited growth of lung cancer, but it cannot be used as an effective indicator of the degree of malignancy and prognosis of lung cancer. Overexpression of EGFR plays an important role in the development of lung cancer and may be an early marker of lung cancer.