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近１０多年的研究证明硒与乳腺癌具有高度的相关性，但是国内外的研究也发现硒与人类的乳腺癌之间没有明显的相关性。最近的研究也认为血硒与乳腺癌转移有一定的关系，可是仍存在争议。实验研究也表明，硒对癌细胞具有双重作用，其原因目前还不清楚。硒水平与ＧＳＨ－ＰＸ活性之间的关系也存在分歧。硒抗乳腺癌的机理尚不明确，但是，一般认为与硒的抗氧化损伤作用、硒能抑制癌细胞生物大分子的合成和硒能提高机体的免疫功能有关。
The past 10 years of research have shown that selenium and breast cancer have a high correlation, but research at home and abroad also found that there is no obvious correlation between selenium and human breast cancer. Recent studies also believe that blood selenium has a certain relationship with breast cancer metastasis, but there is still controversy. Experimental studies have also shown that selenium has a dual effect on cancer cells, and the reason for this is unclear. The relationship between selenium levels and GSH-PX activity also differs. The mechanism of selenium against breast cancer is not yet clear, but it is generally believed that selenium can inhibit the synthesis of antioxidants, selenium can inhibit the synthesis of cancer biomacromolecules and selenium can improve the body’s immune function.