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中枢神经系统疾病可引起脑脊液补体变化。补体经典、替代途径参与细菌性脑膜炎病变过程 ;Alzheimer病可通过外源凝集素途径激活补体 ;重症脑外伤替代途径参与继发性脑损害 ;多发性硬化不但经典途径激活 ,而且补体激活程度和病变严重程度密切相关 ,表明脑脊液补体激活也加重中枢神经系统病变。
Central nervous system diseases can cause changes in cerebrospinal fluid complement. Complement classic, alternative pathways involved in the pathogenesis of bacterial meningitis; Alzheimer’s disease can be activated by lectin pathway complement; severe traumatic brain injury alternative pathways involved in secondary brain damage; multiple sclerosis not only the activation of the classical pathway, and complement activation and The severity of the disease is closely related, indicating that cerebrospinal fluid complement activation also aggravates central nervous system disease.