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目的：探讨红色诺卡氏菌细胞壁骨架（Ｎｏｃａｒｄｉａｒｕｂｒａ Ｃｅｌｌ Ｗａｌｌ Ｓｋｅｌｅｔｏｎ，Ｎ－ ＣＷＳ） 对膀胱肿瘤治疗效果和机理。方法：用Ｎ－ ＣＷＳ注射膀胱癌荷瘤鼠，观察Ｎ－ ＣＷＳ的抑瘤效果及Ｎ－ ＣＷＳ对ＩＬ－ １，ＩＬ－ ２，ＩＬ－ ６ 和ＮＫ活性的影响。结果：注射Ｎ－ ＣＷＳ的膀胱癌荷瘤鼠的抑瘤率为９６２ ％ ；肿瘤对照组小鼠ＩＬ－１ ，ＩＬ－ ２，ＩＬ－６ 水平及ＮＫ 细胞活性均明显低于正常小鼠（ Ｐ＜００１） ，提示荷瘤鼠免疫功能受到抑制。Ｎ－ ＣＷＳ组ＩＬ－ １，ＩＬ－ ２ ，ＩＬ－ ６ 水平及ＮＫ 细胞活性则明显高于肿瘤对照组。结论：Ｎ－ ＣＷＳ对膀胱癌具有明显的抑制作用，其机理可能是通过提高机体的ＩＬ－ １ ，ＩＬ－ ２，ＩＬ－ ６ 水平和ＮＫ 的活性促进机体的抗肿瘤免疫而实现的
Objective: To investigate the therapeutic effect and mechanism of Nocardiarubra Cell Wall Skeleton (N CWS) on bladder cancer. Methods: The tumor-bearing mice were injected with N-CWS to observe the anti-tumor effect of N-CWS and the effect of N-CWS on the activity of IL-1, IL-2, IL- Results: The tumor inhibition rate of bladder cancer bearing mice injected with N-CWS was 962%. The levels of IL-1, IL-2, IL-6 and NK cell activity in tumor control mice were significantly lower than those in normal mice (P <001), suggesting that immune function of tumor-bearing mice was inhibited. The levels of IL-1, IL-2, IL-6 and NK cell activity in N-CWS group were significantly higher than those in tumor control group. CONCLUSIONS: N-CWS has a significant inhibitory effect on bladder cancer, and its mechanism may be achieved through enhancing the body’s anti-tumor immunity by increasing the levels of IL-1, IL-2, IL-6 and NK activity