即使是基础疾病减轻或清除,肾功能衰竭将必然导致剩余的肾功能进行性丧失吗?倘若如此,那么其原因是什么?能否限制其发展?Brenner等为揭示广泛肾部分切除后肾小球内的改变,利用微穿技术对一种有表面肾小球的Munich Wistar鼠进了研究,发现首先是剩余的肾小球肥大,其血流及滤过率增加,其后出现进行性蛋白尿及肾小球硬化,并有肾功能降低。这些改变的直接原因似乎是肾小球毛细血管压(PGC升高。高蛋白,特别是 Even if the underlying disease is reduced or eliminated, renal failure will inevitably lead to progressive loss of the remaining renal function? If so, what is the reason for this? Can it limit its development? Brenner et al. Within the change, the use of micro-wear technology on a surface glomerular Munich Wistar rats into the study and found that the first is the remaining glomerular hypertrophy, the blood flow and filtration rate increased, followed by progressive proteinuria And glomerular sclerosis, and decreased renal function. The immediate cause of these changes appears to be glomerular capillary pressure (elevated PGC, high protein, especially