即使根本的病程级解或消失,还有某种程度的肾衰,难免导致剩余肾功能的进行性丧失吗?如果是这样,这一进展的原因是什么?能缓和它吗? 波士顿Brenner实验室进行的一系列挑战性实验导致了有重大临床意义的一个简单假说。在有适宜于这类研究的浅表肾小球的慕尼黑Wistar鼠广泛肾切除后,Brenner小组使用显微穿刺技术来揭示肾小球内的状况。剩余的肾小球肥大,其血流和滤过率增高。随后蛋白尿和肾小球硬化逐渐发展,肾功能衰退。这些改变似乎是肾小球毛细管压(PGc)升高的直接结果。高蛋白饮食特别是动物性高蛋白可加速这 Even if the underlying course of disease is resolved or disappears, is there a certain degree of renal failure, inevitably lead to the progressive loss of remaining renal function? If so, what is the reason for this progress and can ease it? Boston Brenner Laboratory A series of challenging experiments led to a simple hypothesis of great clinical significance. After extensive nephrectomy in Munich Wistar rats with superficial glomeruli suitable for this type of study, the Brenner team used microscopic techniques to reveal glomerular conditions. The remaining glomerular hypertrophy, increased blood flow and filtration rate. Then proteinuria and glomerulosclerosis gradually developed, renal function decline. These changes appear to be a direct result of elevated glomerular capillary pressure (PGc). High protein diets, especially animal high protein, can speed this up