【摘 要】
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Objective:To investigate glucose metabolic alterations in cerebral cortical subareas using 18F-labeled glucose derivative fluorodeoxyglucose(FDG)micro-positron emission tomography(PET)scanning in a rat renal ischemia/reperfusion(RIR)model.Methods:Small-an
【机 构】
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Department of Anesthesiology,Maternal and Child Health Hospital of Hubei Province,Wuhan 430070,China
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Objective:To investigate glucose metabolic alterations in cerebral cortical subareas using 18F-labeled glucose derivative fluorodeoxyglucose(FDG)micro-positron emission tomography(PET)scanning in a rat renal ischemia/reperfusion(RIR)model.Methods:Small-animal PET imaging in vivo was performed with 18F-labeled FDG as a PET tracer to identify glucose metabolic alterations in cerebral cortical subregions using a rat model of RIR.Results:We found that the average standardized uptake value(SUVaverage)of the cerebral cortical subareas in the RIR group was significantly increased compared to the sham group(P＜0.05).We also found that glucose uptake in different cortical subregions including the left auditory cortex,right medial prefrontal cortex,right para cortex,left retrosplenial cortex,right retrosplenial cortex,and right visual cortex was significantly increased in the RIR group(P＜0.05),but there was no significant difference in the SUVaverage of right auditory cortex,left medial prefrontal cortex,left para cortex,and left visual cortex between the two groups.Conclusion:The 18F-FDG PET data suggests that RIR causes a profound shift in the metabolic machinery of cerebral cortex subregions.
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