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有资料表明,存在于中枢神经系统中的血管紧张素Ⅱ(AⅡ)对外源性注射的吗啡和内源性释放的阿片肽都有拮抗作用,被认为是一种内源性的抗阿片物质。已知在失血性休克时,中枢神经系统中的阿片样物质大量释放,对心血管系统起抑制作用;向中枢注射阿片受体拮抗剂纳洛酮可阻断这种作用,促进休克的恢复和提高动物的存活率。在失血性休克的情
It is reported that angiotensin II (AII) present in the central nervous system is antagonistic to exogenously administered morphine and endogenously released opioid peptides and is considered to be an endogenous anti-opiate substance. It is known that during the hemorrhagic shock, a large amount of opioid in the central nervous system is released, which inhibits the cardiovascular system; injection of naloxone, an opioid receptor antagonist to the central nervous system, blocks this effect and promotes the recovery of shock Improve animal survival rate. In the case of hemorrhagic shock