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本文就近年来对NO的研究及其与休克关系的报道作简要叙述。一、NO的生物学特性 1.化学特性:NO有很强的亲脂性,极易透过生物膜,与血红蛋白、肌球蛋白和可溶性鸟苷酸环化酶上的铁离子有高度亲合性;其可激活鸟苷酸环化酶,生成环-磷酸鸟苷(cGMP),cGMP介导血管平滑肌的舒张,调节局部血流。 2.生物合成:NO由NO合酶(NOS)氧化L-精氨酸(L-Arg)的胍基氮而产生。NOS主要有两种,一类是先天就存在的结构型NOS(cNOS),其活性依赖于NADPH、Ca~(2+)及钙调素的存在。另一类是细胞受到脂多糖(LPS)、细胞因子等刺激后才表达的
This article briefly describes the research on NO and its relationship with shock in recent years. First, the biological characteristics of NO 1. Chemical properties: NO has a strong lipophilic, easily permeable through the biofilm, and hemoglobin, myosin and soluble guanylate cyclase on the iron ions have a high affinity ; It can activate guanylate cyclase, generate cyclic guanosine monophosphate (cGMP), cGMP mediated vascular smooth muscle relaxation, regulate local blood flow. 2. Biosynthesis: NO is produced by the oxidation of guanidino nitrogen of L-arginine (L-Arg) by NO synthase (NOS). There are two main types of NOS, one is congenital existing structural NOS (cNOS), its activity depends on the presence of NADPH, Ca ~ (2+) and calmodulin. The other is the cells by lipopolysaccharide (LPS), cytokines and other stimuli before expression