论文部分内容阅读
检测９２例反复呼吸道感染（ＲＲＴＩ）患儿血清Ｚｎ、Ｍｎ、Ａｌ、Ｃｄ、Ｆｅ、Ｃｕ、Ｐｂ、Ｎｉ、Ｔｉ、Ｃｏ、Ｌｉ、Ｃｒ含量，以及外周血Ｔ细胞亚群、Ｔ细胞增殖功能、血清免疫球蛋白等指标，结果表明ＲＲＴＩ患儿血清Ｚｎ、Ｆｅ、Ｐｂ、Ｎｉ、Ｔｉ、Ｃｏ、Ｌｉ均值明显低于正常对照组，各年龄中亦以Ｚｎ、Ｆｅ、Ｃｏ、Ｌｉ降低多见；外周血Ｔ细胞增殖功能、ＣＤ３＋细胞百分率、ＣＤ４＋细胞百分率以及ＣＤ４＋／ＣＤ８＋细胞比值均显著下降，ＣＤ８＋细胞百分率明显高于正常儿童。上述免疫功能指标与血清Ｆｅ、Ｚｎ、Ｃｒ、Ｎｉ等存在显著性相关关系。提示ＲＲＴＩ时不仅免疫功能广泛受损，而且伴有多种微量元素缺乏或失衡；血清微量元素缺乏、免疫功能低下与ＲＲＴＩ三者间可能互为因果，临床上及时补充铁、锌等微量元素对防治ＲＲＴＩ的发生发展是十分必要的。
The levels of serum Zn, Mn, Al, Cd, Fe, Cu, Pb, Ni, Ti, Co, Li and Cr in 92 children with recurrent respiratory tract infection (RRTI) were measured. T cell subsets, T cell proliferation, Serum immunoglobulin and other indicators, the results showed that RRTI children with serum Zn, Fe, Pb, Ni, Ti, Co, Li average was significantly lower than the normal control group, also reduced to Zn, Fe, Co, Li more common in all ages; Peripheral blood T cell proliferation, CD3 + cell percentage, CD4 + cell percentage and CD4 + / CD8 + cell ratio were significantly decreased, the percentage of CD8 + cells was significantly higher than normal children. The above immune function indicators and serum Fe, Zn, Cr, Ni and other significant correlation exists. It is suggested that not only the immune function is widely impaired but also the deficiency or imbalance of many trace elements in RRTI. The lack of serum trace elements, immune dysfunction and RRTI may be the cause and effect of each other. Clinically, iron, zinc and other trace elements Prevention and treatment of the occurrence of RRTI is very necessary.