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目的检测血清脑钠肽(BNP)在慢性阻塞性肺疾病(COPD)合并慢性肺源性心脏病代偿期、失代偿期治疗前后的变化,探讨其临床应用价值。方法收集沛县人民医院2011年6月至2012年12月呼吸科收治的COPD急性加重期、COPD合并慢性肺源性心脏病代偿期、失代偿期各50例患者,采用电化学发光法检测其血清BNP水平。结果 COPD急性加重期组BNP稍高于正常值,而COPD合并慢性肺源性心脏病代偿期、失代偿期血清BNP明显升高,与COPD急性加重期比较差异有统计学意义(P<0.05),且慢性肺源性心脏病治疗后临床症状好转,血清BNP水平随之下降。结论血清BNP水平的检测可作为COPD合并肺源性心脏病的早期诊断、严重程度的判断及治疗效果评价的指标。
Objective To investigate the changes of serum brain natriuretic peptide (BNP) before and after decompensation and decompensation in patients with chronic obstructive pulmonary disease (COPD) complicated with chronic cor pulmonale, and to explore its clinical value. Methods Pei County People’s Hospital from June 2011 to December 2012 admitted to the Department of Respiratory COPD acute exacerbation of COPD with chronic cor pulmonale decompensated, decompensated in 50 patients, the use of electrochemical luminescence Serum BNP levels were measured. Results The BNP in COPD group was slightly higher than normal while COPD with chronic cor pulmonale decompensated and decompensated serum BNP was significantly higher than that in acute exacerbation of COPD (P < 0.05), and clinical symptoms after treatment of chronic cor pulmonale improved, serum BNP levels decreased. Conclusion Serum BNP level can be used as an early diagnosis, severity judgment and evaluation of therapeutic effect in patients with COPD complicated with pulmonary heart disease.