贲门失弛缓症是食管一种异常运动,以食管蠕动消失、下食管括约肌压力增高及吞咽时不能松弛为特征。作者采用局部注射一种神经末梢释放乙酰胆碱的抑制剂——肉毒杆菌毒素,能有效治疗该病。本文介绍用此剂治疗贲门失弛缓症的双盲、对照结果。 方法:所有患者治疗前先由临床评分,作食管测压、咽喉食管X线拍片和食管潴留的放射性核素检查等。经内镜检查确诊后,随机于括约肌内四点注射80单位肉毒杆菌毒素(每 Cardiac achalasia is an abnormal movement of the esophagus characterized by the disappearance of esophageal peristalsis, increased esophageal sphincter pressure, and relaxation when swallowing. The authors used a local injection of a nerve terminal release of acetylcholine inhibitor - botulinum toxin, can effectively treat the disease. This article presents a double-blind, controlled trial of this agent for the treatment of achalasia in the cardia. Methods: All patients before treatment by the clinical score, for esophageal manometry, throat esophageal X-ray film and esophageal retention of radionuclide examination. After endoscopy confirmed diagnosis, random four in the sphincter injections of 80 units of botulinum toxin (each