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目的观察尼美舒利联合甲硝唑治疗慢性牙周炎的效果。方法 60例确诊为慢性牙周炎的患者,随机分为观察组与对照组各30例。对照组予单纯甲硝唑治疗,观察组在对照组基础上加用尼美舒利治疗,1个月后比较两组相关指标变化。结果观察组牙龈指数、牙周袋深度、牙松动度评分、菌斑指数、附着丧失、肿瘤坏死因子-α、白细胞介素-1水平均低于对照组,差异有统计学意义。结论尼美舒利联合甲硝唑治疗慢性牙周炎疗效优于单用甲硝唑治疗。
Objective To observe the effect of nimesulide and metronidazole in the treatment of chronic periodontitis. Methods Sixty patients diagnosed as chronic periodontitis were randomly divided into observation group and control group with 30 cases each. The control group was treated with metronidazole alone. The observation group was treated with nimesulide on the basis of the control group, and the changes of the related indexes were compared after one month. Results The gingival index, periodontal pocket depth, tooth mobility index, plaque index, attachment loss, tumor necrosis factor-α and interleukin-1 levels in the observation group were all lower than those in the control group. The difference was statistically significant. Conclusion Nimesulide combined with metronidazole in the treatment of chronic periodontitis is superior to metronidazole alone.