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吡嗪酰胺是肺结核短程治疗方案中的重要组成药物。作者通过电镜检查,观察各种含吡嗪酰胺的治疗方案对肝脏的影响。共21例初治肺结核,以往无肝病史,部份患者嗜酒(相当于每日80g酒精,时间10年以上)。第1组单用吡嗪酰胺30mg/kg/d,治疗15天,共7例,其中3例嗜酒,平均年龄35.7(25～55)岁。治疗前肝活检示2例轻度病变:腊样质增多和肝窦轻度充血,其余5例正常。治疗15天后肝活检3例正常,余4例示巨线粒体(megamitochondries,MM)伴类晶状体(corpo paracristallins,CP)1例、平滑
Pyrazinamide is an important component of tuberculosis short-course treatment programs. The author examined by electron microscopy to observe the effects of various pyrazinamide-containing regimens on the liver. A total of 21 cases of newly diagnosed tuberculosis, no history of liver disease in the past, some patients with alcohol (equivalent to 80g daily alcohol, more than 10 years). The first group with pyrazinamide 30mg / kg / d, for 15 days, a total of 7 cases, of which 3 cases of alcohol, the average age of 35.7 (25 to 55) years old. Liver biopsy before treatment showed 2 cases of mild lesions: increased wax samples and sinusoidal hyperemia, and the remaining 5 cases were normal. Three of the liver biopsies were normal 15 days after treatment and 1 of 4 patients with megamitochondris (MM) corpo parsristallins (CP) showed smooth appearance