三氟甲基和(或)卤素取代的嘧啶和脂肪或杂环羧酸(3 eq),以水和乙腈(1∶1)为溶剂,在硝酸银(4 eq)和过硫酸铵(5 eq)催化下,60℃反应2 h,可发生Minisci反应,24例中21例收率8%~68%。二氯或三氯取代的嘧啶收率较低。 (4 eq) and ammonium persulfate (5 eq) with trifluoro and / or halogen substituted pyrimidines and aliphatic or heterocyclic carboxylic acids (3 eq) in water and acetonitrile ) Catalyzed reaction at 60 ℃ for 2 h, Minisci reaction occurred in 24 cases, 21 cases of 8% to 68% yield. Dichloro- or trichloro-substituted pyrimidines yield lower yields.