Klotho基因是一种与寿命和衰老表型(如动脉硬化、骨质疏松、肺气肿等)相关的基因,该基因缺陷的小鼠会出现与人类衰老相似的临床表型。随着增龄,与衰老相关性疾病也日益增多,成为影响人类健康长寿的重要因素,为此本文从分子遗传学角度上就klotho基因及其多态性与衰老相关性疾病的关系研究进展做综合分析,以寻求该基因在衰老相关性疾病的发生和发展中所起作用的线索。 The Klotho gene is a gene associated with lifespan and aging phenotypes such as atherosclerosis, osteoporosis, emphysema and the like, and mice deficient in this gene exhibit a clinical phenotype similar to human aging. With aging, aging-related diseases are also increasing, becoming an important factor affecting human health and longevity, this paper from the molecular genetic point of view klotho gene and its polymorphism and aging-related diseases research progress Comprehensive analysis to find clues to the role of this gene in the occurrence and development of aging-related diseases.