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目的探讨KLOTHO基因第四外显子C-1818T多态性与中国苏皖地区汉族人群急性心肌梗死(AMI)的关系。方法入选229例AMI患者(AMI组)和235例经相关检查排除冠状动脉疾病者(对照组),采用PCR及基因芯片技术检测KLOTHO基因C-1818T多态性的基因型,同时测定甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和血糖等临床生化指标。结果与对照组相比,AMI组老年人(≥60岁)和男性患者的CT基因型频率均明显升高(P均<0.05),在调整多因素并经logistic回归分析后,KLOTHO基因CT基因型与老年人和男性AMI无显著关联性。结论 KLOTHO基因C-1818T多态性CT基因型可能是中国苏皖地区汉族人群AMI的易感基因型。在存在多种动脉粥样硬化相关危险因素的情况下,携带该基因型的老年人和男性较易发生AMI。
Objective To investigate the relationship between C-1818T polymorphism of exon 4 of KLOTHO gene and acute myocardial infarction (AMI) in Han nationality in Jiangsu and Anhui Provinces. Methods A total of 229 patients with AMI (AMI group) and 235 patients with coronary artery disease (control group) were enrolled in the study. Genotypes of C-1818T polymorphism in KLOTHO gene were detected by PCR and gene chip technique. The levels of triglyceride , Low density lipoprotein cholesterol, high-density lipoprotein cholesterol and blood glucose and other clinical biochemical indicators. Results Compared with the control group, the frequencies of CT genotypes were significantly higher in the elderly (≥60 years) and male patients in the AMI group (all P <0.05). After adjustment for multiple factors and logistic regression analysis, the CT genotype There was no significant association between AMI and elderly and men. Conclusion The CT genotype of KLOTHO gene C-1818T polymorphism may be the susceptible genotype of AMI in Han population in Jiangsu and Anhui Provinces. In the presence of multiple risk factors associated with atherosclerosis, AMI is more likely to occur in elderly and men with this genotype.