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目的探讨血清缺氧诱导因子-1(HIF-1)和组织P53的表达水平与乳腺癌预后的关系。方法悬浮芯片法检测117例乳腺原发浸润性导管癌、10例复发乳腺浸润性导管癌、20例乳腺良性肿瘤和31例正常人血清中HIF-1含量,并利用免疫组织化学检测其组织中P53蛋白的表达。结果原发、复发乳腺癌血清HIF-1和P53蛋白表达水平明显高于良性肿瘤和正常对照组(p<0.01),复发癌高于原发癌(p<0.05);血清HIF-1和组织P53蛋白水平在不同的病理学特征中差异有显著性(p<0.05);乳腺癌患者的HIF-1与P53表达水平呈正相关(r=0.544,=0.000)。结论血清HIF-1参与了乳腺浸润性导管癌的病理过程,是评估乳腺浸润性导管癌患者预后的重要指标。
Objective To investigate the relationship between the expression of serum hypoxia inducible factor-1 (HIF-1) and tissue P53 and the prognosis of breast cancer. Methods The levels of HIF-1 in 117 cases of primary invasive ductal carcinoma, 10 cases of recurrent breast invasive ductal carcinoma, 20 cases of benign breast tumor and 31 cases of normal human breast cancer were detected by suspension chip. Immunohistochemistry P53 protein expression. Results The serum levels of HIF-1 and P53 protein in primary and recurrent breast cancer were significantly higher than those in benign and normal controls (p <0.01) P53 protein levels in different pathological features were significantly different (p <0.05); breast cancer HIF-1 and P53 expression was positively correlated (r = 0.544, = 0.000). Conclusions Serum HIF-1 is involved in the pathological process of breast invasive ductal carcinoma and is an important index to evaluate the prognosis of invasive ductal carcinoma.