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应用酶联免疫吸附试验法测定了30例慢性活动型肝炎及24例慢性重型肝炎患者血清可溶性肿瘤坏死因子受体（sTNFR）水平。结果显示：慢性重型肝炎及慢性活动型肝炎患者sTNFR水平显著升高，尤以慢性重型肝炎患者为甚，升高程度与总胆红素呈正相关，与凝血酶原活动度呈负相关。对24例慢性重型肝炎患者进一步分析表明；伴有感染或肝肾综合征时，sTNFR水平显著高于无感染或肝肾综合征患者，最终死亡者其水平也显著高于存活者。提示测定慢性活动型肝炎和慢性重型肝炎患者rrrrrrrrn血清sTNFR水平对判断病情及预测转归有一定的价值。
Serum levels of soluble tumor necrosis factor receptor (sTNFR) were measured in 30 patients with chronic active hepatitis and 24 patients with chronic severe hepatitis by enzyme-linked immunosorbent assay. The results showed that the levels of sTNFR in patients with chronic severe hepatitis and chronic active hepatitis were significantly increased, especially in patients with chronic severe hepatitis. The degree of increase was positively correlated with total bilirubin and negatively correlated with the activity of prothrombin. Further analysis of 24 patients with chronic severe hepatitis showed that patients with infection or hepatorenal syndrome had significantly higher levels of sTNFR than those without infection or with hepatorenal syndrome and eventually with significantly higher levels of survivors. Prompt determination of chronic active hepatitis and chronic severe hepatitis serum sTNFR levels to determine the prognosis of the disease and prognosis of a certain value.