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目的证实脂蛋白（ａ）是动脉粥样硬化性心脑血管疾病的独立危险因素，探讨心脑血管疾病脂类危险因素中最有价值的危险因子。方法观察诊断明确的冠心病２３６例，脑卒中２４７例，以２４５例健康人和２１８例其他疾病患者为对照，对脂蛋白（ａ）、载脂蛋白Ａ１、载脂蛋白Ｂ、血脂作综合分析。结果冠心病、脑卒中血清脂蛋白（ａ）水平均显著高于健康人组和其它疾病组，并与其它血脂指标均不相关，各指标对心脑血管病的判断价值从高到低依次为：载脂蛋白Ａ１、高密度脂蛋白胆固醇、载脂蛋白Ｂ、脂蛋白（ａ）、低密度脂蛋白胆固醇、总胆固醇、甘油三酯。结论脂蛋白（ａ）是动脉粥样硬化性心脑血管疾病的独立危险因素，脂蛋白（ａ）、载脂蛋白Ａ１、载脂蛋白Ｂ、甘油三酯为心脑血管疾病脂类危险因素中最有价值的危险因子。
Objective To confirm that lipoprotein (a) is an independent risk factor for atherosclerotic cardiovascular and cerebrovascular diseases and explore the most valuable risk factors for lipid risk factors in cardiovascular and cerebrovascular diseases. Methods A total of 236 cases of coronary heart disease and 247 cases of stroke were observed. 245 cases of healthy subjects and 218 cases of other diseases were selected as controls. The levels of lipoprotein (a), apolipoprotein A1, apolipoprotein B and lipids were analyzed comprehensively . Results The levels of serum lipoprotein (a) in coronary heart disease and stroke were significantly higher than those in healthy people and other disease groups, and were not related to other blood lipid indicators. The judging value of each index on cardio-cerebral vascular diseases was : Apolipoprotein A1, high-density lipoprotein cholesterol, apolipoprotein B, lipoprotein (a), low-density lipoprotein cholesterol, total cholesterol, triglycerides. Conclusion Lipoprotein (a) is an independent risk factor for atherosclerotic cardiovascular and cerebrovascular diseases. Lipoprotein (a), apolipoprotein A1, apolipoprotein B and triglyceride are risk factors of cardiovascular and cerebrovascular diseases The most valuable risk factor.