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目的:探讨内脂素与胰岛素抵抗的关系及其在妊娠期糖尿病(GDM)发病中的作用。方法:采用病例对照的研究方法,通过检测40例GDM孕妇和40例正常孕妇的血清内脂素、空腹血糖(FPG)和空腹胰岛素(FINS)水平,计算HO-MA稳态模型胰岛素抵抗指数(IRI),比较两组胰岛素抵抗程度的差异,并进一步分析内脂素与GDM孕妇胰岛素抵抗之间的关系。结果:GDM组的血清内脂素、FPG、FINS和IRI均明显高于对照组(P<0.01)。相关分析表明:GDM孕妇的血清内脂素水平与IRI呈正相关(γ=0.568,P=0.000)。结论:GDM孕妇的血清内脂素水平较正常孕妇明显增高。内脂素水平与胰岛素抵抗呈正相关,提示其与GDM的发生有关。
Objective: To investigate the relationship between visfatin and insulin resistance and its role in the pathogenesis of gestational diabetes mellitus (GDM). Methods: The serum insulin, FPG and FINS in 40 pregnant women with GDM and 40 normal pregnant women were measured by case-control study to calculate the index of insulin resistance of HO-MA homeostasis model IRI). The differences of insulin resistance between the two groups were compared, and the relationship between visfatin and insulin resistance in GDM pregnant women was further analyzed. Results: Serum visfatin, FPG, FINS and IRI in GDM group were significantly higher than those in control group (P <0.01). Correlation analysis showed that serum visfatin levels in pregnant women with GDM were positively correlated with IRI (γ = 0.568, P = 0.000). Conclusion: The level of serum visfatin in pregnant women with GDM is significantly higher than that of normal pregnant women. The level of visfatin was positively correlated with insulin resistance, suggesting that it correlates with the development of GDM.