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阿根廷布宜诺斯艾利斯A Posa-das医院胃肠病科负责人PabloMazure,对一项比较Misoprostol和甲腈咪胍对溃疡疗效分别在欧洲、阿根廷和日本进行的世界性多中心试验进行了观察,结果如下。方法:为多中心、随机、双盲、内窥镜对照试验。参加试验的为经内窥镜检查证实溃疡直径为0.3～2.0cm的病人。剂量欧洲:Misoprostol 200μg,每日四次,饭前和就寝时服;甲腈咪胍300mg,每日四次。阿根廷:Misoprostol 200μg,每日四次,饭后和就寝时服;甲腈咪胍300μg,每日四次。日本:Misoprostol200μg,每日四次,饭后和就寝时服;甲腈咪胍200mg,每日四次。
PabloMazure, director of gastroenterology at A Posa-das Hospital in Buenos Aires, Argentina, conducted a multicenter trial comparing the effects of Misoprostol and cimetidine on ulcer efficacy in Europe, Argentina and Japan respectively Observations, the results are as follows. Methods: A multicenter, randomized, double-blind, endoscopic control trial. To participate in the trial for the endoscopic examination confirmed ulcer diameter 0.3 ~ 2.0cm patients. Dosage Europe: Misoprostol 200μg, four times daily, before meals and at bedtime; Cimetidine 300mg, four times a day. Argentina: Misoprostol 200μg, four times daily, after meals and during bedtime; Cimetidine 300μg, four times daily. Japan: Misoprostol200μg, four times a day, after meals and bedtime; Cimetidine 200mg, four times a day.