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目的:研究频域光学相干断层成像(spectral domain optical coherence tomography,SD-OCT)定量和定性检测指标在接受玻璃体腔内注射贝伐单抗的年龄相关性黄斑变性(agerelated macular degeneration,AMD)患者人群中的变化,以评估这些指标是否可以用于预测治疗后视力情况。方法:回顾性分析66眼61例未进行过AMD相关治疗的患者接受至少3mo玻璃体腔内注射贝伐单抗治疗的情况。治疗前后SD-OCT定量检测指标[中央视网膜厚度(central foveal thickness,CFT),外界膜(external limiting membrane,ELM)和椭圆区(ellipsoid zone,EZ)长度]和定性检测指标进行分析和比较。同时,分析这些指标和治疗前后的视力的相关性。结果:平均视力(Log MAR)、CFT、ELM和EZ长度治疗前为0.62±0.41、419.3±110.0μm、378.2±377.2μm和156.4±253.7μm,治疗后为0.53±0.44、325.8±117.9μm、547.1±421.5μm和173.1±207.1μm。治疗前视力和CFT(rs=0.27)、ELM长度(rs=-0.30)及ELM断裂(rs=0.43)有相关性。治疗后视力同样和治疗后ELM长度相关(rs=-0.40)。治疗后视力和治疗前视力(rs=0.66)、ELM长度(rs=-0.35)和ELM断裂(rs=0.46)相关。结论:研究显示:治疗前视力、ELM长度和ELM断裂可以用于预测治疗后视力。
OBJECTIVE: To study the quantitative and qualitative detection of spectral domain optical coherence tomography (SD-OCT) in patients with age-related macular degeneration (AMD) receiving intravitreal bevacizumab In order to assess whether these indicators can be used to predict post-treatment visual acuity. Methods: Sixty-six eyes of 66 patients who had not undergone AMD-related therapy were retrospectively analyzed for at least 3 months of intravitreal bevacizumab. The indexes of SD-OCT, including central foveal thickness (CFT), external limiting membrane (ELM) and length of ellipsoid zone (EZ), were compared before and after treatment. At the same time, analyze the correlation between these indexes and visual acuity before and after treatment. Results: Log MAR, CFT, ELM and EZ lengths were 0.62 ± 0.41, 419.3 ± 110.0μm, 378.2 ± 377.2μm and 156.4 ± 253.7μm before treatment, 0.53 ± 0.44, 325.8 ± 117.9μm, 547.1 ± 421.5 μm and 173.1 ± 207.1 μm. There was a correlation between pretreatment visual acuity and CFT (rs = 0.27), ELM length (rs = -0.30), and ELM rupture (rs = 0.43). Visual acuity after treatment also correlated with ELM length after treatment (rs = -0.40). Post-treatment visual acuity was associated with pre-treatment visual acuity (rs = 0.66), ELM length (rs = -0.35), and ELM rupture (rs = 0.46). CONCLUSIONS: Studies have shown that pre-treatment vision, ELM length, and ELM rupture can be used to predict post-treatment vision.