论文部分内容阅读
目的:通过检测IVF-ET患者取卵后血清雌激素水平的变化模式,探讨其在预测妊娠中的意义。方法:纳入因榆卵管因素或男性因素行IVF-ET的患者62例(75个周期)。对行IVF-ET的患者,在取卵后隔日监测血清雌二醇(E_2)水平,并比较其在妊娠组与未孕组的差异。结果:取卵后,血E_2水平在妊娠组与未孕组均迅速降低,在取卵后2,4,6,8 d,两组间无统计学差异。在妊娠周期,血E_2平均水平在取卵后10d降至最低,之后逐渐上升。妊娠组与未孕组之间E_2水平的差异从取卵后10d开始可以检测出(分别为816.4±537.6pg/ml和189.5±69.3pg/ml)(P<0.05)。在未孕周期,10d的E_2水平(189.5±69.3pg/ml)显著低于8d(989.2±581.5pg/ml)(P<0.05)。结论:在取卵后8d和10d连续测2次血E_2水平,有助于早期发现妊娠:妊娠患者的E_2水平在10d出现上升预示妊娠,而10d出现剧陡降时,往往预示妊娠失败。
OBJECTIVE: To investigate the changes of serum estrogen levels in ovariectomized patients (IVF-ET) and to explore its significance in predicting pregnancy. Methods: Sixty-two patients (75 cycles) with IVF-ET due to Ulmus or Male factors were enrolled. Serum estradiol (E2) levels were monitored on the next day after ovulation in patients with IVF-ET and their differences between pregnant and nonpregnant groups were compared. Results: After oviposition, blood E 2 levels decreased rapidly in both pregnant and non-pregnant groups. There was no significant difference between the two groups at 2, 4, 6 and 8 days after ovulation. In the gestation cycle, the average level of blood E2 decreased to the lowest level 10 days after ovulation, then gradually increased. The differences in E 2 levels between pregnancy and non-pregnant groups were detectable at 10 days after ovulation (816.4 ± 537.6 pg / ml and 189.5 ± 69.3 pg / ml, respectively) (P <0.05). During the second trimester of pregnancy, E 2 levels at 10 days (189.5 ± 69.3 pg / ml) were significantly lower than those at 8 days (989.2 ± 581.5 pg / ml) (P <0.05). CONCLUSION: E 2 level measured continuously on the 8th day and the 10th day after ovulation is helpful for the early detection of pregnancy. The increase of E 2 levels in pregnancy indicates the pregnancy on the 10th day and the sudden decline on the 10th day often indicates the failure of pregnancy.