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一般脑血流SPECT要求示踪剂在脑内滞留1小时左右。为研究在脑中增加~(99m)Tc-络合物的摄取及延长滞留的可能,作者对一系列DADT衍生物进行比较(包括6种氨基乙基-和4种氨基已基-衍生物),以了解化学结构与体内分布的关系。~(69)Tc-衍生物用高效液相色谱仪(HpLc)分离为两个主要部分(A和B相,可能为几何异构体),测定其在辛醇-缓冲液系统中的~(99m)Tc辛醇(计数)/缓冲液(ml)净计数(CPM/ml),以此获得~(99m)Tc
General cerebral blood flow SPECT requires tracer to stay in the brain about 1 hour. In order to study the possibility of uptake of 99m Tc-complex and prolonged retention in the brain, the authors compared a series of DADT derivatives (including 6 aminoethyl- and 4 aminohexyl-derivatives) To understand the relationship between chemical structure and in vivo distribution. The ~ (69) Tc-derivative was separated into two major parts (A and B phases, probably geometric isomers) by high performance liquid chromatography (HpLc) and its (- 99m) Tc Octanol (count) / Buffer (ml) net count (CPM / ml) to obtain ~ (99m) Tc