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近年来我国在病毒性肝炎病原学、免疫学、流行病学及疫苗的研制和应用等方面取得了较大进展。病原学 1、甲肝病毒分离及动物模型的建立:在传代人肾细胞及人肺二倍体细胞中分离病毒成功。用甲肝病毒实验感染恒河猴,成功地建立了甲肝动物模型.这些工作仅仅是开始,但给甲肝疫苗的制备和甲肝的实验研究带来了希望。 2、乙肝基因工程和单克隆抗体的研究:HBsAg(乙型肝炎表面抗原),在大肠菌和小鼠L细胞上表达成功,分泌乙型肝炎表面抗体(抗HBs)
In recent years, China has made great progress in the development and application of viral hepatitis etiology, immunology, epidemiology and vaccines. Etiology 1, Hepatitis A Virus Isolation and Establishment of Animal Models: The virus was successfully isolated from human renal cells and human lung diploid cells. Infection of rhesus monkeys with Hepatitis A virus successfully established animal model of Hepatitis A. These efforts are only the beginning, but the preparation of hepatitis A vaccine and the experimental study of hepatitis A hope. 2, hepatitis B gene engineering and monoclonal antibody research: HBsAg (hepatitis B surface antigen), expressed successfully in coliforms and mouse L cells, the secretion of hepatitis B surface antibodies (anti-HBs)