论文部分内容阅读
目的通过探讨抗-SSA抗体阳性人群临床特点,揭示该抗体的疾病预警价值,以利于自身免疫病(AID)的早期发现。方法对体检检测抗-SSA抗体阳性人群的临床表现及实验室相关指标进行回顾性分析及调查。结果(1)抗-SSA抗体阳性人群男女比例差异很大,男女比例为1∶2.95。不同性别少年组阳性率差异不大;中青年组女性阳性率大于男性,差异有统计学意义(P<0.01);老年组男性阳性率高于女性,差异有统计学意义(P<0.01)。(2)抗-SSA抗体阳性组疲劳乏力、腹部不适、关节肿痛、皮肤病变、口干、眼干、淋巴结症状等均明显高于阴性组。(3)抗-SSA抗体阳性组实验室检查,血液有形成分减低,尿常规异常,血沉增快,肝功酶类升高,Ig G升高,C_3、C_4降低,RF升高等均高于阴性组(P<0.01)。结论对于血液系统、消化系统、淋巴结、关节等组织器官反复出现病变患者及早行抗-SSA等自身抗体检测,以利于原发性干燥综合征等AID的早发现。
Objective To explore the clinical features of anti-SSA antibody positive population and to reveal the early warning value of this antibody in order to facilitate the early detection of autoimmune diseases (AIDs). Methods Retrospective analysis and investigation of the clinical manifestations and laboratory related indexes of physical examination to detect anti-SSA antibody positive population. Results (1) The ratio of male to female in anti-SSA antibody positive group varies greatly, with the ratio of male to female being 1: 2.95. There was no significant difference in the positive rate among different sex groups. The positive rate of female in middle-aged and young group was higher than that in male (P <0.01). The positive rate of male in old group was higher than that in female (P <0.01). (2) The group of anti-SSA antibody positive fatigue, abdominal discomfort, joint swelling and pain, skin lesions, dry mouth, dry eyes, lymph node symptoms were significantly higher than the negative group. (3) In the laboratory of anti-SSA antibody positive group, the blood components reduced, abnormal urine, erythrocyte sedimentation rate increased, hepatic enzymes increased, Ig G increased, C_3, C_4 decreased and RF increased Negative group (P <0.01). Conclusions Autoantibodies such as anti-SAA autoantibodies were detected in patients with recurrent lesions in tissues and organs such as blood system, digestive system, lymph nodes and joints to facilitate the early detection of AID such as Sjogren’s syndrome.