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据Kim C 2013年1月27日(Nature,doi:10.1038/nature11799)报道,美国桑福德-伯纳姆医学研究所与约翰.霍普金斯大学的研究人员合作,用一种遗传性心脏病患者的皮肤细胞培育出心肌细胞,并在培养皿中诱导出心脏病模型,再现了该病发作时的主要特征。这一成果有助于人们更好地研究该病,测试新的治疗方法。这一遗传性心脏病叫心律失常性右心室发育不良/右心室心肌病(ARVD/C)。大多数患者在20岁之前没有征兆,因此很难研究其进展情况和相应疗法。要证明培养皿中的疾病模型与成人患者疾病之间具有临床相关性是非常困难的。ARVD/C症状通常到青年期才会显出来,而研究人员用的干细胞在性质上属于胚胎。但该研究有一项关键突破,诱导胚胎细胞拥有了成人心肌的新陈代谢。
According to Kim C, Jan. 27, 2013 (Nature, doi: 10.1038 / nature11799), the Sanford-Burnham Institute of Medicine in the United States, working with Johns Hopkins researchers, used a hereditary heart The patient’s skin cells develop cardiomyocytes and induce a heart disease model in the Petri dish, reproducing the main features of the onset of the disease. This result helps people better study the disease and test new treatments. This hereditary heart disease is arrhythmogenic right ventricular dysplasia / right ventricular cardiomyopathy (ARVD / C). Most patients have no symptoms until the age of 20, making it difficult to study their progress and therapies. It is very difficult to prove that there is a clinical correlation between the disease model in Petri dishes and the disease in adult patients. ARVD / C symptoms usually appear until adolescence, and researchers use stem cells that are embryos in nature. But there’s a key breakthrough in that research, which is to induce embryonic cells to have the metabolic properties of adult myocardium.