放射敏感性(辐射致死率)在很大程度上决定于照射后关键性放射敏感组织的增殖改变——造血综合症与胃肠综合症。环核苷酸与细胞代谢和增殖过程的调节有关。所以环核苷酸对代谢和增殖的效应可能是细胞辐射反应的特异改变的关键,从而使整个机体放射敏感性或是增高,或是减低。本文报导用显微放射自显影术和辐射致死率研究给环核苷酸和茶碱后中国田鼠(Cricetulus griseus)骨髓细胞群体的增殖反应。 Radiosensitivity (radiolethality) is largely determined by the proliferation of key radiation-sensitive tissue after irradiation—hematopoietic syndrome and gastrointestinal syndrome. Cyclic nucleotides are involved in the regulation of cellular metabolism and proliferation processes. Therefore, the effects of cyclic nucleotides on metabolism and proliferation may be the key to the specific changes in the radiation response of cells, so that the whole body’s radiosensitivity is either increased or decreased. In this paper, we reported the proliferation response of cyclic nucleotides and theophylline in Chinese mice (Cricetulus griseus) bone marrow cell population using microscopic autoradiography and radiation lethality.