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目的探讨变应性鼻炎特异性鼻黏膜激发试验(SNPT)与血清特异性IgE(sIgE)在变应性鼻炎患者检测中的一致性,并对激发前后嗜酸性粒细胞(EOS)百分比和血清sIgE相关性进行分析。方法对80例常年性尘螨变应性鼻炎患者进行SNPT,Unicap检测血清sIgE的等级,采用Kendall’s tau_b检验对激发前后鼻腔分泌物中EOS百分比进行相关性分析。结果患者鼻黏膜激发试验阳性与血清sIgE阳性有一定相关性,且SNPT后鼻分泌物中EOS百分比的增加与sIgE等级呈正相关。结论鼻黏膜激发试验阳性可以作为过敏性鼻炎的一个诊断指标,激发前后鼻腔分泌物中EOS的百分比变化也可以用于评价过敏性鼻炎的严重程度。
Objective To investigate the consistency of SNPT and serum IgE (sIgE) in the detection of allergic rhinitis, and to evaluate the percentage of eosinophils (EOS) and serum sIgE Relevance analysis. Methods Eighty patients with perennial allergic rhinitis were treated with SNPT and Unicap for the determination of serum sIgE levels. Correlation analysis was performed using the Kendall’s tau_b test for the percentage of EOS in nasal secretions before and after challenge. Results The positive nasal mucosa test was positively correlated with serum sIgE, and the increase of percentage of EOS in nasal secretions was positively correlated with sIgE level after SNPT. Conclusions The positive nasal mucosal stimulation test can be used as a diagnostic indicator of allergic rhinitis. The percentage of EOS in the nasal secretion before and after challenge can also be used to evaluate the severity of allergic rhinitis.