非酒精性脂肪肝是影响公众健康的一系列相关疾病,最近研究发现短期使用尿苷可以阻止一些药物引起的脂肪肝,但长期使用加剧了脂肪肝的形成。现对尿苷如何通过改变蛋白质乙酰化、糖基化,降低胰岛素信号通路蛋白质的磷酸化水平,从而影响肝脏中脂肪代谢的一些机理进行了综述。 Non-alcoholic fatty liver disease is a series of related diseases that affect public health. Recently, we found that short-term use of uridine can prevent fatty liver caused by some drugs, but the long-term use aggravates the formation of fatty liver. Now, we summarize some of the mechanisms by which uridine affects the metabolism of fat in the liver by changing the acetylation and glycosylation of proteins and decreasing the phosphorylation of insulin signaling pathway proteins.