所有在荷兰Dijkzigt大学医院进行检查的孕妇都在第一次检查时检测HBsAg,HB-sAg阳性孕妇所生的新生儿将被列入研究计划。进入研究的新生儿出生体重至少为2000g,5分钟的Apgar新生儿评分在7以上。作者将174名新生儿随机分成两组。第1组86人,接种4针10μg疫苗;第2组88人,接种4针μg疫苗。两组均按DTP-脊髓 All pregnant women at Dijkzigt University Hospital in the Netherlands will be tested for HBsAg at the first screening and neonates born to HBsAg-positive pregnant women will be included in the study plan. Newborns entering the study have a birth weight of at least 2000 g and a 5-minute Apgar Neonatal score of 7 or higher. The authors randomized 174 newborns to two groups. In Group 1, 86 were vaccinated with 4 doses of 10 μg of vaccine; Group 2, 88 were inoculated with 4 doses of μg vaccine. Both groups according to DTP-spinal cord