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目的:检测乳腺丝氨酸蛋白酶抑制剂(marray serine proteinase inhibitor,Maspin)在唾液腺黏液表皮样癌中的表达,及其与唾液腺黏液表皮样癌患者临床病理特征之间的关系。方法:应用免疫组织化学方法,分别对58例唾液腺黏液表皮样癌的癌组织及其癌旁正常腺体组织标本行Maspin蛋白含量的半定量测定,与各临床病理指标进行统计学分析,采用SPSS13.0统计学软件进行非参数检验。结果:Maspin蛋白在唾液腺黏液表皮样癌的癌组织中的表达显著高于癌旁正常腺体组织(P<0.001),唾液腺黏液表皮样癌组织中Maspin蛋白的表达与淋巴结转移(P=0.020)、术后转移(P=0.008)呈负相关,与总体生存状况呈正相关(P=0.028)。结论:Maspin蛋白的检测在唾液腺黏液表皮样癌患者中可能具有较好的预后判断价值。
OBJECTIVE: To detect the expression of Maspin in salivary mucoepidermoid carcinoma and its relationship with clinicopathological features of salivary gland mucoepidermoid carcinoma. Methods: Immunohistochemistry was used to detect the expression of Maspin protein in 58 specimens of salivary gland mucoepidermoid carcinoma and its adjacent normal gland tissue specimens respectively. Statistical analysis was made with the clinicopathological parameters. .0 Statistical software for non-parametric tests. Results: The expression of Maspin protein in salivary gland mucoepidermoid carcinoma was significantly higher than that in adjacent normal gland tissue (P <0.001), Maspin protein expression and lymph node metastasis in salivary gland mucoepidermoid carcinoma (P = 0.020) , Postoperative metastasis (P = 0.008) was negatively correlated with overall survival status (P = 0.028). Conclusion: The detection of Maspin protein in salivary gland mucoepidermoid carcinoma patients may have a better prognostic value.