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了解慢性丙型肝炎（丙肝）不同感染方式患者血清ＰＣⅢ和ＨＡ浓度变化，探讨其临床意义。采用放射免疫测定法，分别检测输血后丙肝３０例和散发性丙肝３３例血清ＰＣⅢ和ＨＡ值，并与正常人１５例对照。结果显示，输血后丙肝组血清ＰＣⅢ和ＨＡ均值分别为３１６．７±２２０．３μｇ／ｍｌ和４６９．９±２６７．２μｇ／ｍｌ，显著高于散发性丙肝的１９８．７±８８．１μｇ／ｍｌ和２９２．９±２０２．９μｇ／ｍｌ（Ｐ＜０．０１）；两组丙肝患者的血清ＰＣⅢ和ＨＡ均值，均显著高于正常对照组的８８．０±１８．５μｇ／ｍｌ和６０．５±１８．６μｇ／ｍｌ（Ｐ＜０．０１）。分析认为，血清ＰＣⅢ和ＨＡ升高反映肝组织纤维化程度，而输血后丙肝较散发性丙肝更易发展成肝硬化。
To investigate the changes of serum PCⅢ and HA in patients with chronic hepatitis C (hepatitis C) infection and explore their clinical significance. Radioimmunoassay was used to detect serum PCⅢ and HA in 30 cases of hepatitis C and 33 cases of sporadic HCV after transfusion, respectively, and 15 cases were compared with normal controls. The results showed that the average serum levels of PCⅢ and HA in blood serum of patients with hepatitis C after transfusion were 316.7 ± 220.3μg / ml and 469.9 ± 267.2μg / ml, respectively, which were significantly higher than that of 198.7 ± 88.1μg / ml And 292.9 ± 202.9μg / ml respectively (P <0.01). The mean serum PCⅢ and HA in two groups of hepatitis C patients were significantly higher than those in the normal control group (88.0 ± 18.5μg / ml and 60.5 ± 18.6 μg / ml (P <0.01). Analysis, elevated serum PC Ⅲ and HA reflect the degree of liver fibrosis, and hepatitis C after transfusion more sporadic hepatitis C more likely to develop cirrhosis.