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目的:研究PTEN与bcl-2、FasL的表达与异位子宫内膜的关系。方法:用免疫组化法检测PTEN与bcl-2、FasL在正常子宫内膜,异位内膜及在位内膜的表达。结果:(1)正常子宫内膜组:bcl-2在增生期的表达显著高于分泌期(P<0.05),FasL及PTEN在增生期的表达显著低于分泌期(P<0.05),即三者在正常子宫内膜细胞的表达均有明显周期性;(2)异位内膜组(OEM及AM):bcl-2、FasL及PTEN的表达在增生期和分泌期的表达均无统计学差异(P>0.05)。即在异位子宫内膜中的bcl-2、FasL及PTEN呈持续表达且失去周期性;(3)在位内膜组(OEM及AM):与正常子宫内膜组相似,三者在增生期和分泌期的表达均有差异,其中,FasL与PTEN在分泌期的表达高于增生期,bcl-2在增生期的表达则高于分泌期,差异均有统计学意义(P<0.05);(4)3组内膜中的表达比较:FasL及bcl-2在异位内膜组的表达均高于在位内膜组及正常子宫内膜(P<0.05),PTEN在异位内膜组的表达均低于在位内膜组及正常子宫内膜(P<0.05);FasL、bcl-2及PTEN在正常内膜组的表达与在位内膜组无统计学差异(P>0.05)。结论:bcl-2、FasL及PTEN的表达变化在子宫内膜异位症的发生发展过程中起着重要作用。
Objective: To study the relationship between the expression of PTEN, bcl-2, FasL and ectopic endometrium. Methods: The expressions of PTEN, bcl-2 and FasL in normal endometrium, endometrium and eutopic endometrium were detected by immunohistochemistry. Results: (1) In normal endometrium group, the expression of bcl-2 in proliferative phase was significantly higher than that in secretory phase (P <0.05). The expression of FasL and PTEN in proliferative phase was significantly lower than that in secretory phase (P <0.05) The expressions of bcl-2, FasL and PTEN in the eutopic endometrium group (OEM and AM) showed no statistical significance in both proliferative and secretory phase Learning difference (P> 0.05). That is, the expression of bcl-2, FasL and PTEN in ectopic endometrium continued to be expressed and lost the cycle; (3) Eutopic endometrium (OEM and AM): similar to normal endometrium, The expression of FasL and PTEN in the secretory phase was higher than that in the proliferative phase, while the expression of bcl-2 in the proliferative phase was higher than that in the secretory phase, with significant difference (P <0.05) ; (4) The expression of FasL and bcl-2 in eutopic endometrium was higher than that in eutopic endometrium and normal endometrium (P <0.05) (P <0.05). The expressions of FasL, bcl-2 and PTEN in normal endometrium group were not significantly different from those in eutopic endometrium group (P> 0.05). Conclusion: The expression of bcl-2, FasL and PTEN plays an important role in the development of endometriosis.