用组化技术对荷瘤小鼠不同时期免疫器官的变化进行观察,结果发现荷瘤小鼠早、中期免疫器官处于增生状态,吞噬细胞反应明显,免疫应答较强,但在终末期,荷瘤小鼠的免疫器官萎缩、纤维化,应答反应低下。说明荷瘤小鼠早、中期免疫器官受肿瘤细胞抗原的刺激产生免疫应答,对机体产生保护性反应,而晚期的免疫器官萎缩、纤维化、功能受到抑制,对机体无明显防御反应。 Tissue technology was used to observe the changes of immune organs in the tumor-bearing mice at different stages. The results showed that the early and mid-term immune organs were hyperplastic, the phagocytes responded well and the immune response was strong. However, in the terminal stage, Mouse immune organs atrophy, fibrosis, response to low response. Tumor bearing mice early and mid-term immune organs by tumor cell antigen immune response, the body produces a protective response, and late immune atrophy, fibrosis, function was inhibited, no significant defensive response to the body.