论文部分内容阅读
A族链球菌(简称GrAS),主要的致病因子,一是位于细胞表面的M蛋白;其二是透明质酸酶荚膜,它们都具有抗吞噬功能。非致病性的GrAS二者皆没有,因此容易被吞噬。对以上现象的研究,近年来主要集中在GrAS菌体构造与补体的相互作用上,如链球菌的粘肽、细胞壁,细胞膜与磷壁酸等对补体替代途径(ACP)的活化能力。然而,作为一个完整的GrAS个体,它与补体是如何相互作用的,却一无所知。本文报导了致病性与非致病性的GrAS在活化ACP能力上的差别,并认为这种差别是由于M蛋白所造成。
Group A Streptococcus (referred to as GrAS), the main pathogenic factor, one is located in the cell surface M protein; the second is hyaluronidase capsular, they are anti-phagocytic function. Non-pathogenic GrAS is neither, so it is easily engulfed. In recent years, the research on these phenomena has mainly focused on the interaction between GrAS cell structure and complement, such as Streptococcus mutans, cell wall, cell membrane and the teichoic acid activation of complement alternative pathway (ACP). However, as a complete GrAS, it does not know how it interacts with complement. This paper reports the differences in the ability of pathogenic and non-pathogenic GrAS to activate ACP and concludes that this difference is due to M protein.