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一般说来,组织对酵母菌属新型隐球菌感染的反应是很轻的,只有少数病例发生哺中性细胞反应。这是由于酵母菌的多糖荚膜不能引起机体强烈炎症反应的缘故。1978年Macher等人报导:隐球菌感染的患者,其血清中C_3和补体替代途径(ACP)的B因子水平下降,这说明酵母菌能活化ACP。从新型隐球菌的某些成份可使ACP活化提示:酵母菌的某些成份有使正常血清中补体碎片产生趋化的可能性。因此,隐球菌感染的组织病理学可能与酵母菌活化ACP和产
In general, the response of tissues to Cryptococcus neoformans infection is very mild, with only a few cases of PMN. This is because the yeast polysaccharide capsule can not cause the body’s strong inflammatory response. In 1978, Macher et al. Reported that patients with cryptococcosis had a decreased level of factor B in the serum C_3 and complement replacement pathway (ACP), suggesting that yeast activated ACP. Activation of ACP from certain components of C. neoformans suggests that certain components of yeast have the potential to chemotactize complement fragments in normal serum. Therefore, the histopathology of cryptococcal infection may interact with yeast activation of ACP and production