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目的：探讨使用大剂量干扰素（ＩＦＮα）治疗慢性丙型肝炎（ＣＡＨ）的效果。方法：使用大剂量ＩＦＮα，每天６００万Ｕ，连续投药３周，以后每周３次间断投药２１周，共计２４周，治疗ＣＡＨ５０例。观察治疗前后血清ＨＣＶＲＮＡ与ＡＬＴ的变化，以此作为ＩＦＮ疗效的判定指标。结果：ＩＦＮ治疗ＣＡＨ有效率为６８％，停药６个月后有３４％复发。结论：ＩＦＮ的疗效与ＣＡＨ的基因亚型有关（Ⅲ型疗效显著，Ⅱ型较差），与ＩＦＮ的剂量无明显关系。
Objective: To explore the use of high-dose interferon (IFN α) in the treatment of chronic hepatitis C (CAH) results. Methods: The use of high-dose IFN α, 6 million U per day for 3 weeks of continuous administration, intermittent administration of 3 weeks after 21 weeks, a total of 24 weeks, the treatment of 50 cases of CAH. Observed before and after treatment of serum HCV RNA and ALT changes as a guideline for the determination of IFN efficacy. Results: The effective rate of IFN treatment for CAH was 68%, and 34% of relapse occurred after 6 months of withdrawal. Conclusion: The therapeutic effect of IFN is related to the genotypes of CAH (type Ⅲ has a significant curative effect and type Ⅱ is poor), and has no obvious relationship with the dose of IFN.