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探讨复方米非司酮配伍米索前列醇治疗稽留流产两种方法的可行性和副反应。将150例稽留流产患者随机分为A组和B组,每组75例,所有患者均为口服复方米非司酮2片bid×2 d,d 3晨A组口服米索前列醇3片,B组阴道后穹隆放置米索前列醇3片,待妊娠物排出后再行清宫术。观察妊娠物排出情况、治疗后的副反应、清宫时宫颈软化扩张程度及一次清宫成功率。结果 B组流产有效率90.66%略高于A组86.66%,但无明显统计学差异(P>0.05);B组总副反应率41.33%明显低于低于A组56.00%,差异有统计学意义(P<0.05);B组和A组宫颈软化、扩张总有效率无明显差异(P>0.05),一次清宫成功率无差异(P>0.05)。复方米非司酮配伍米索前列醇治疗稽留流产两种方法均可行,流产效果好,但阴道给药副反应明显下降。
To explore the feasibility and side effects of two methods of compound mifepristone and misoprostol in the treatment of missed abortion. 150 cases of missed abortion were randomly divided into A group and B group, 75 cases in each group, all patients were oral administration of mifepristone two tablets bid × 2 d, d 3 morning group A oral administration of misoprostol 3, B group vaginal posterior fornix placed misoprostol 3, to be discharged after pregnancy, curettage. Observe the discharge of pregnancy, side effects after treatment, the degree of cervical softening during the Qing Dynasty and the success rate of a curettage. Results The effective rate of abortion in group B was slightly higher than that in group A (90.66%, 86.66%), but there was no significant difference (P> 0.05). The total adverse reaction rate in group B was significantly lower than that in group A (41.33% vs 56.00%, the difference was statistically significant (P <0.05). There was no significant difference in the total effective rate of cervical softening and expansion between group B and group A (P> 0.05). There was no difference in the success rate of one grade of curettage between the two groups (P> 0.05). Compound mifepristone and misoprostol treatment of missed abortion two methods are feasible, abortion effect is good, but the side effects of vaginal administration decreased significantly.