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目的:检测慢性牙周炎患者采用不同方法进行牙周基础治疗前、后不同时期龈沟液中IL-27的浓度,探讨IL-27在牙周炎发病过程中所起的作用。方法:选择60例中、重度慢性牙周炎患者,随机分为A组(交叉象限刮治)和B组(上、下半口刮治),每组30例,另选牙周健康者30例为C组(对照组)。A组和B组于基线和治疗后1、2、3周分别取样,记录每例患者的各项牙周临床指标。ELISA法检测龈沟液IL-27的浓度。应用SPSS 17.0软件包对数据进行统计学分析。结果:治疗后第2、3周,A、B 2组的PD、AL、BI、PLI均有明显改善,各分组象限与基线比较IL-27浓度均升高,而A组PD、AL、BI及IL-27浓度的变化较B组显著,差异有统计学意义;A组治疗后3周各分组象限IL-27浓度与C组无显著差异。IL-27浓度与PD、AL、BI、PLI呈负相关。结论:龈沟液IL-27可作为牙周病防治及疗效评估的潜在靶分子,交叉象限与上、下半口龈下刮治相比,短期效果更显著。
Objective: To detect the concentration of IL-27 in gingival crevicular fluid of patients with chronic periodontitis by different methods before and after periodontal basic treatment, and to explore the role of IL-27 in the pathogenesis of periodontitis. Methods: Sixty patients with moderate or severe chronic periodontitis were randomly divided into group A (crossover quadrant cure) and group B (upper half and lower half cure), with 30 cases in each group and 30 healthy persons with periodontal disease Cases for the C group (control group). Group A and group B were sampled at baseline and at 1, 2, and 3 weeks after treatment, and each periodontal clinical index of each patient was recorded. The concentration of IL-27 in gingival crevicular fluid was detected by ELISA. Data was statistically analyzed using SPSS 17.0 software package. Results: The levels of PD, AL, BI and PLI in group A and group B were significantly improved at the second and third week after treatment. The concentrations of IL-27 in group A and group B were significantly higher than those in baseline And IL-27 concentrations were significantly different from those in group B, the difference was statistically significant. There was no significant difference in concentration of IL-27 between group A and group C three weeks after treatment. The concentration of IL-27 was negatively correlated with PD, AL, BI and PLI. Conclusion: Gingival crevicular fluid IL-27 can be used as a potential target for prevention and treatment of periodontal disease. Compared with subgingival scaling in upper and lower halves, the short-term effect is more significant.