心肌功能障碍是多器官功能不全预后不良的标志之一。在多器官功能不全中,心肌功能障碍是由多因素参与、在多个环节上造成的。缺血缺氧、众多细胞因子和介质的参与、神经内分泌环境改变等是造成心肌功能受损的重要原因,这包括心肌的能量代谢、离子转运、受体及受体后功能等方面的改变,甚至有心肌结构损伤和凋亡等。然而其具体机制都还有许多不明之处。 Myocardial dysfunction is one of the hallmarks of poor prognosis in multiple organ dysfunction. In multiple organ dysfunction, myocardial dysfunction is caused by multiple factors involved in many aspects. Ischemia and hypoxia, the involvement of many cytokines and mediators, the changes of neuroendocrine environment and other factors are the important reasons of impaired myocardial function, including the changes of myocardial energy metabolism, ion transport, receptor and post-receptor function, Even myocardial damage and apoptosis. However, its specific mechanism is still a lot of ambiguity.