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目的探讨脓毒症患者N末端前体脑钠肽(N-terminal pro-type natriuretic peptide,NT-proBNP)、肌钙蛋白I(cardiac troponin I,cTn-I)、肌酸激酶(creatine kinase,CK)和肌酸激酶同工酶(CK-MB)、心肌脂肪酸结合蛋白(heart-type fatty acid-binding protein,H-FABP)的水平及其临床意义。方法选择2015年7月-2016年7月我院收治的脓毒症患者60例(脓毒血症组),一般感染患者30例(一般感染组),同时选取同期健康体检者30例作为正常对照组,采用电化学发光法检测各组血清NT-proBNP水平,化学发光法检测cTn-I,快速检测法检测CK和CK-MB,采用双抗体夹心酶联免疫试验法检测H-FABP。结果脓毒症组与正常对照组和一般感染组比较,感染部位差异无统计学意义(P>0.05);一般脓毒症组、严重脓毒症组和脓毒性休克组的NT-proBNP、cTn-I和H-FABP均依次显著升高,差异有统计学意义(P<0.05);与正常对照组和一般感染组比较,脓毒症组患者血清NT-proBNP、cTn-I、CK和H-FABP水平显著增高,差异有统计学意义(P<0.05)。结论脓毒症患者血清NT-proBNP、cTn-I和H-FABP水平均显著升高,可作为判断脓毒症心功能的良好指标。
Objective To investigate the expression of N-terminal pro-type natriuretic peptide (NT-proBNP), cardiac troponin I (cTn-I) and creatine kinase ) And CK-MB, and heart-type fatty acid-binding protein (H-FABP) in patients with chronic hepatitis B and their clinical significance. Methods From July 2015 to July 2016, 60 patients with sepsis (sepsis group) and 30 patients with general infection (general infection group) were enrolled in our hospital. 30 healthy subjects were selected as normal In the control group, serum NT-proBNP levels were detected by electrochemiluminescence assay, cTn-I by chemiluminescence assay, CK and CK-MB by rapid test, and H-FABP by sandwich enzyme-linked immunosorbent assay. Results There was no significant difference in the infection sites between the sepsis group and the normal control group and the general infection group (P> 0.05). NT-proBNP, cTn in the sepsis group, severe sepsis group and septic shock group The levels of NT-proBNP, cTn-I, CK and H in sepsis group were significantly higher than those in normal control group and general infection group (P <0.05) -FABP levels were significantly increased, the difference was statistically significant (P <0.05). Conclusions Serum levels of NT-proBNP, cTn-I and H-FABP in sepsis patients were significantly increased, which could be used as a good indicator of cardiac function in septic patients.