Uu感染患者精浆中细胞因子对精子活力的影响

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  目的:观察解脲支原体(Ureaplasma urealyticum,Uu)感染患者精浆中细胞因子的变化对精子活力的影响.意义:探讨Uu对精子活力影响的免疫机制.方法:采用Elisa方法对Uu阳性组(44例),治疗后转阴组(30例),正常对照组(14例)精浆中的IL-8、IL-10、TNF-α进行检测.使用全自动精子分析仪对精子活力(路径速度、前向速度)进行分析.结果:Uu阳性组的IL-8、IL-10、TNF-α分别为157.2±74.6、315.4±112.5、223.6±89.7(pg/ml),明显高于正常对照组IL-8、IL-10、TNF-α的78.7±28.6、158.2±56.3、84.3±47.9两组差异显著(P<0.01).治疗转阴后该组IL-8、IL-10、TNF-α分别为114.3+61.5、237.2±86.1、152.6±83.5以显著下降.同时精子活力亦随三种细胞因子的下降而明显提高.结论:Uu可引起精浆中细胞因子紊乱,使精子的活力下降,从而生育能力下降.
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