Preparation, characterization of monoclonal antibodies against interleukin-13 receptor α2 chain and

来源 :全军免疫学第七届学术交流会暨免疫学新进展主题论坛 | 被引量 : 0次 | 上传用户：jxnydxlhy1

【摘要】

：

【作者】

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Xu ZW Li Q Zhang T Song CJ Dong Y Jin BQ

【机构】

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Department of Immunology, 17 Changlexi Street, Xi'an 710032

【出处】

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全军免疫学第七届学术交流会暨免疫学新进展主题论坛

【发表日期】

：

2009年12期

【关键词】

：

interleukin-13 receptor o2 glioma monoclonal antibody ELISA

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　　Despite advances in surgical technology and radiation therapy,the prognosis in the patients with malignant glioma remains poor.Recent studies show that interleukin-13 receptor αt2 chain (IL-13Rα2) might be a potential biomarker and molecular target for therapy of several kinds of tumors including glioblastomas.Thus,recombinant IL-13Rα2 was used as immunogens in the B lymphocyte hybridoma technique.A total of 13 anti-IL-13Rα2 monoclonal antibodies (mAbs) with high specificity were obtained,among which 7 could be used in flow cytometry,10 could be used in Western blot while 2 could be used in immunohistochemical staining.

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