Objective:Explore the clinical efficacy and safety of the immunoadsorption assisted treatment of children with refractory autoimmune diseases.Methods:Use HA280 type resin perfusion machine for four times of whole blood immunoadsorption treatment for one case of a 4-year-old child combined with severe dermatomyositis and pulmonary infection,one case of 9-year -old child with severe allergic purpura combined with gastrointestinal bleeding,intestinal perforation,after intestinal tract partial hepatectomy,one case of 11-year-old child with systemic juvenile idiopathic arthritis combined with head and facial cellulites and macrophage activation syndrome.