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Objective:Analysis the HLA-DRB 1 allele polymorphism characteristics of juvenile idiopathic arthritis in children of Guangdong.Methods:To analyze 14 HLA-DRB 1 alleles of 94 cases of JIA children and 113 cases of healthy with Sequencespecific primer-polymerase chain reaction (SSP/PCR) technology,and analyze the distribution of these genes in each group.